For research use only. Not for therapeutic Use.
AZD2423(Cat No.:I022861)is a selective antagonist of the chemokine receptor CCR2, developed by AstraZeneca for the treatment of inflammatory and neuropathic pain disorders. CCR2 mediates monocyte recruitment and activation in response to its ligand CCL2 (MCP-1), playing a central role in inflammation and neuro-immune signaling. By blocking CCR2 activity, AZD2423 reduces inflammatory cell infiltration and modulates pain pathways. It has been evaluated in clinical trials for chronic pain, rheumatoid arthritis, and other inflammatory diseases. This compound is a valuable tool in immunology, inflammation, and pain research.
CAS Number | 1229603-37-5 |
Synonyms | 4-[(2R)-4-tert-butylpiperazine-2-carbonyl]-N-(4-chloro-3-fluorophenyl)piperazine-1-carboxamide |
Molecular Formula | C20H29ClFN5O2 |
Purity | ≥95% |
IUPAC Name | 4-[(2R)-4-tert-butylpiperazine-2-carbonyl]-N-(4-chloro-3-fluorophenyl)piperazine-1-carboxamide |
InChI | InChI=1S/C20H29ClFN5O2/c1-20(2,3)27-7-6-23-17(13-27)18(28)25-8-10-26(11-9-25)19(29)24-14-4-5-15(21)16(22)12-14/h4-5,12,17,23H,6-11,13H2,1-3H3,(H,24,29)/t17-/m1/s1 |
InChIKey | SRWQVWAIVQXPJY-QGZVFWFLSA-N |
SMILES | CC(C)(C)N1CCN[C@H](C1)C(=O)N2CCN(CC2)C(=O)NC3=CC(=C(C=C3)Cl)F |
Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |