AZD2423

For research use only. Not for therapeutic Use.

  • CAT Number: I022861
  • CAS Number: 1229603-37-5
  • Molecular Formula: C20H29ClFN5O2
  • Molecular Weight: 425.93
  • Purity: ≥95%
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AZD2423(Cat No.:I022861)is a selective antagonist of the chemokine receptor CCR2, developed by AstraZeneca for the treatment of inflammatory and neuropathic pain disorders. CCR2 mediates monocyte recruitment and activation in response to its ligand CCL2 (MCP-1), playing a central role in inflammation and neuro-immune signaling. By blocking CCR2 activity, AZD2423 reduces inflammatory cell infiltration and modulates pain pathways. It has been evaluated in clinical trials for chronic pain, rheumatoid arthritis, and other inflammatory diseases. This compound is a valuable tool in immunology, inflammation, and pain research.


CAS Number 1229603-37-5
Synonyms

4-[(2R)-4-tert-butylpiperazine-2-carbonyl]-N-(4-chloro-3-fluorophenyl)piperazine-1-carboxamide

Molecular Formula C20H29ClFN5O2
Purity ≥95%
IUPAC Name 4-[(2R)-4-tert-butylpiperazine-2-carbonyl]-N-(4-chloro-3-fluorophenyl)piperazine-1-carboxamide
InChI InChI=1S/C20H29ClFN5O2/c1-20(2,3)27-7-6-23-17(13-27)18(28)25-8-10-26(11-9-25)19(29)24-14-4-5-15(21)16(22)12-14/h4-5,12,17,23H,6-11,13H2,1-3H3,(H,24,29)/t17-/m1/s1
InChIKey SRWQVWAIVQXPJY-QGZVFWFLSA-N
SMILES CC(C)(C)N1CCN[C@H](C1)C(=O)N2CCN(CC2)C(=O)NC3=CC(=C(C=C3)Cl)F
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