For research use only. Not for therapeutic Use.
AZD1940 (Cat No.: I003530) is a synthetic cannabinoid receptor agonist developed by AstraZeneca for the treatment of pain. It acts as a potent agonist at both CB1 and CB2 receptors, aiming to provide analgesic effects through modulation of the endocannabinoid system. Despite promising preclinical results, clinical trials revealed limited efficacy and central nervous system side effects, leading to discontinued development. AZD1940 remains valuable in research as a reference compound for studying cannabinoid receptor pharmacology, pain modulation, and drug discovery in neuropharmacology.
| CAS Number | 881413-29-2 |
| Synonyms | N-[2-tert-butyl-1-[(4,4-difluorocyclohexyl)methyl]benzimidazol-5-yl]ethanesulfonamide |
| Molecular Formula | C20H29F2N3O2S |
| Purity | ≥95% |
| InChI | InChI=1S/C20H29F2N3O2S/c1-5-28(26,27)24-15-6-7-17-16(12-15)23-18(19(2,3)4)25(17)13-14-8-10-20(21,22)11-9-14/h6-7,12,14,24H,5,8-11,13H2,1-4H3 |
| InChIKey | ZAGGGZCIFUQHOH-UHFFFAOYSA-N |
| SMILES | CCS(=O)(=O)NC1=CC2=C(C=C1)N(C(=N2)C(C)(C)C)CC3CCC(CC3)(F)F |
| Reference | [1]. Jarkko Kalliomäki, et al. Evaluation of the analgesic efficacy and psychoactive effects of AZD1940, a novel peripherally acting cannabinoid agonist, in human capsaicin-induced pain and hyperalgesia. Clin Exp Pharmacol Physiol. 2013 Mar;40(3):212-8. [2]. Magnus Schou, et al. Radiolabeling of the cannabinoid receptor agonist AZD1940 with carbon-11 and PET microdosing in non-human primate. Nucl Med Biol. 2013 Apr;40(3):410-4. |
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