For research use only. Not for therapeutic Use.
AZD-1678 (Cat No.: I022853) is a selective serotonin 5-HT6 receptor antagonist developed for research into cognitive enhancement and neurological disorders. By blocking 5-HT6 receptors, it modulates neurotransmitter release, including acetylcholine, dopamine, and glutamate, which are critical for learning, memory, and mood regulation. Researchers have explored AZD-1678 for potential applications in Alzheimer’s disease, schizophrenia, and cognitive impairment. Although clinical development was limited, it remains a valuable pharmacological tool for studying serotonin receptor biology and investigating therapeutic strategies in neuropsychiatric and cognitive research.
CAS Number | 942137-41-9 |
Synonyms | 2,3-dichloro-N-(5-fluoro-3-methoxypyrazin-2-yl)benzenesulfonamide |
Molecular Formula | C11H8Cl2FN3O3S |
Purity | ≥95% |
InChI | InChI=1S/C11H8Cl2FN3O3S/c1-20-11-10(15-5-8(14)16-11)17-21(18,19)7-4-2-3-6(12)9(7)13/h2-5H,1H3,(H,15,17) |
InChIKey | NWSUDJQTTGDPIR-UHFFFAOYSA-N |
SMILES | COC1=NC(=CN=C1NS(=O)(=O)C2=C(C(=CC=C2)Cl)Cl)F |
Reference | [1]. Nicholas Kindon, et al. Discovery of AZD-2098 and AZD-1678, Two Potent and Bioavailable CCR4 Receptor Antagonists. ACS Med Chem Lett. 2017 Sep 1;8(9):981-986. |
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