AZ194

• CAT Number: I045167
• CAS Number: 2241651-99-8
• Molecular Formula: C34H31F2N3O3
• Molecular Weight: 567.63
• Purity: ≥95%
• Synonyms: [4-[(3-fluorophenyl)methoxy]-3-methoxyphenyl]-[4-[1-[(3-fluorophenyl)methyl]benzimidazol-2-yl]piperidin-1-yl]methanone
• InChI: InChI=1S/C34H31F2N3O3/c1-41-32-20-26(12-13-31(32)42-22-24-7-5-9-28(36)19-24)34(40)38-16-14-25(15-17-38)33-37-29-10-2-3-11-30(29)39(33)21-23-6-4-8-27(35)18-23/h2-13,18-20,25H,14-17,21-22H2,1H3
• InChIKey: HDKZBBHJFURFLF-UHFFFAOYSA-N
• SMILES: COC1=C(C=CC(=C1)C(=O)N2CCC(CC2)C3=NC4=CC=CC=C4N3CC5=CC(=CC=C5)F)OCC6=CC(=CC=C6)F

AZ194（Cat No.:I045167）is a potent and selective inhibitor of spleen tyrosine kinase (Syk), a critical mediator of immune receptor signaling in B cells, mast cells, and myeloid cells. By blocking Syk activity, AZ194 suppresses downstream pathways involved in inflammation, autoimmunity, and allergic responses. It has demonstrated strong activity in preclinical models of inflammatory and immune-mediated disorders, including asthma, rheumatoid arthritis, and lupus. AZ194 is a valuable research tool for elucidating Syk-dependent mechanisms and exploring therapeutic strategies targeting immune dysregulation while minimizing off-target effects in drug discovery and development.