AZ13824374

• CAT Number: I044106
• Molecular Formula: C30H39FN8O2
• Molecular Weight: 562.68
• Purity: ≥95%
• Synonyms: (1R,9S,12R)-13-[8-[[1-(2-fluoro-2-methylpropyl)piperidin-4-yl]amino]-3-methyl-[1,2,4]triazolo[4,3-b]pyridazine-6-carbonyl]-12-propan-2-yl-11,13-diazatricyclo[7.3.1.02,7]trideca-2,4,6-trien-10-one
• InChI: InChI=1S/C30H39FN8O2/c1-17(2)25-26-21-9-7-6-8-19(21)14-24(28(40)33-25)38(26)29(41)23-15-22(27-35-34-18(3)39(27)36-23)32-20-10-12-37(13-11-20)16-30(4,5)31/h6-9,15,17,20,24-26,32H,10-14,16H2,1-5H3,(H,33,40)/t24-,25+,26+/m0/s1
• InChIKey: NGXAMXNWIHBLBN-JIMJEQGWSA-N
• SMILES: CC1=NN=C2N1N=C(C=C2NC3CCN(CC3)CC(C)(C)F)C(=O)N4[C@H]5CC6=CC=CC=C6[C@@H]4[C@H](NC5=O)C(C)C

AZ13824374（Cat No.:I044106）is a selective and potent small-molecule inhibitor targeting salt-inducible kinase 2 (SIK2), a member of the AMP-activated protein kinase (AMPK) family involved in metabolic regulation, inflammatory signaling, and cell survival pathways. By inhibiting SIK2, AZ13824374 modulates downstream transcriptional regulators such as CREB-regulated transcription coactivators (CRTCs) and class IIa HDACs, making it a valuable tool in inflammation, metabolic disease, and oncology research. It is particularly useful for studying macrophage polarization, cytokine signaling, and metabolic reprogramming. AZ13824374 supports the development of therapies targeting immune-metabolic dysfunction and inflammatory disorders.