AXL-IN-13

• CAT Number: I042460
• CAS Number: 2376928-82-2
• Molecular Formula: C34H41FN6O5
• Molecular Weight: 632.72
• Purity: ≥95%
• Synonyms: N-cyclohexyl-3-[3-fluoro-4-[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxyanilino]-1-methylpyrazole-4-carboxamide
• InChI: InChI=1S/C34H41FN6O5/c1-40-22-26(34(42)38-23-7-4-3-5-8-23)33(39-40)37-24-9-10-30(27(35)19-24)46-29-11-12-36-28-21-32(31(43-2)20-25(28)29)45-16-6-13-41-14-17-44-18-15-41/h9-12,19-23H,3-8,13-18H2,1-2H3,(H,37,39)(H,38,42)
• InChIKey: QBRQTJMZEYORSP-UHFFFAOYSA-N
• SMILES: CN1C=C(C(=N1)NC2=CC(=C(C=C2)OC3=C4C=C(C(=CC4=NC=C3)OCCCN5CCOCC5)OC)F)C(=O)NC6CCCCC6

AXL-IN-13 (Cat No.: I042460) is a potent and selective small molecule inhibitor of AXL kinase, a member of the TAM (TYRO3, AXL, MER) receptor tyrosine kinase family implicated in cancer progression, metastasis, and drug resistance. By blocking AXL signaling, AXL-IN-13 disrupts tumor cell survival, invasion, and epithelial-to-mesenchymal transition (EMT). It is widely used in oncology research to explore targeted therapies and overcome resistance mechanisms. AXL-IN-13 is a valuable tool for preclinical studies on AXL-driven malignancies and immune evasion pathways.

Reference

[1]. Chan S, et al. Discovery of 3-Aminopyrazole Derivatives as New Potent and Orally Bioavailable AXL Inhibitors. J Med Chem. 2022 Nov 24;65(22):15374-15390.
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