AWL-II-38.3

• CAT Number: I045054
• CAS Number: 1135205-94-5
• Molecular Formula: C23H18F3N5O3
• Molecular Weight: 469.42
• Purity: ≥95%
• Synonyms: N-[2-methyl-5-[[3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)benzoyl]amino]phenyl]-1,2-oxazole-5-carboxamide
• InChI: InChI=1S/C23H18F3N5O3/c1-13-3-4-17(10-19(13)30-22(33)20-5-6-28-34-20)29-21(32)15-7-16(23(24,25)26)9-18(8-15)31-11-14(2)27-12-31/h3-12H,1-2H3,(H,29,32)(H,30,33)
• InChIKey: IYUFHBXMTTXZBE-UHFFFAOYSA-N
• SMILES: CC1=C(C=C(C=C1)NC(=O)C2=CC(=CC(=C2)N3C=C(N=C3)C)C(F)(F)F)NC(=O)C4=CC=NO4

AWL-II-38.3（Cat No.:I045054）is a selective small-molecule inhibitor targeting SHP2 (Src homology region 2-containing protein tyrosine phosphatase 2), a key regulator of RAS/MAPK signaling pathways. By blocking SHP2 activity, AWL-II-38.3 disrupts oncogenic signaling cascades associated with growth factor receptors and mutant RAS-driven cancers. This compound is particularly valuable in cancer research, especially for tumors exhibiting resistance to kinase inhibitors. AWL-II-38.3 serves as a tool to explore SHP2’s role in cellular proliferation, differentiation, and survival. It is intended for in vitro or in vivo preclinical studies only—not for clinical or diagnostic use.

Reference

AWL-II-38.3 is a selective small-molecule inhibitor targeting SHP2 (Src homology region 2-containing protein tyrosine phosphatase 2), a key regulator of RAS/MAPK signaling pathways. By blocking SHP2 activity, AWL-II-38.3 disrupts oncogenic signaling cascades associated with growth factor receptors and mutant RAS-driven cancers. This compound is particularly valuable in cancer research, especially for tumors exhibiting resistance to kinase inhibitors. AWL-II-38.3 serves as a tool to explore SHP2’s role in cellular proliferation, differentiation, and survival. It is intended for in vitro or in vivo preclinical studies only—not for clinical or diagnostic use.