For research use only. Not for therapeutic Use.
AVJ16（Cat No.:I044034）is a potent and selective inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1), an enzyme involved in tryptophan catabolism and immune regulation within the tumor microenvironment. By blocking IDO1 activity, AVJ16 prevents the conversion of tryptophan to kynurenine, thereby restoring T-cell function and promoting anti-tumor immune responses. It is a valuable compound in cancer immunotherapy research, particularly in studies aiming to overcome tumor-induced immune suppression. AVJ16 supports exploration of combination strategies with immune checkpoint inhibitors and enhances understanding of metabolic-immune interactions in oncology and inflammatory disease models.
| CAS Number | 2775241-92-2 |
| Synonyms | [4-(1,3-benzodioxol-5-yl)piperazin-1-yl]-[4-[[2-(hydroxymethyl)indol-1-yl]methyl]phenyl]methanone |
| Molecular Formula | C28H27N3O4 |
| Purity | ≥95% |
| IUPAC Name | [4-(1,3-benzodioxol-5-yl)piperazin-1-yl]-[4-[[2-(hydroxymethyl)indol-1-yl]methyl]phenyl]methanone |
| InChI | InChI=1S/C28H27N3O4/c32-18-24-15-22-3-1-2-4-25(22)31(24)17-20-5-7-21(8-6-20)28(33)30-13-11-29(12-14-30)23-9-10-26-27(16-23)35-19-34-26/h1-10,15-16,32H,11-14,17-19H2 |
| InChIKey | SBMDRXUGWAAAMV-UHFFFAOYSA-N |
| SMILES | C1CN(CCN1C2=CC3=C(C=C2)OCO3)C(=O)C4=CC=C(C=C4)CN5C6=CC=CC=C6C=C5CO |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
