Avatrombopag maleate - CAS 677007-74-8

Avatrombopag, also known as AKR-501, YM477, AS 1670542 or E5501, is a novel orally-active thrombopoietin (TPO) receptor agonist. AKR-501 specifically targeted the TPO receptor and stimulated megakaryocytopoiesis throughout the development and maturation of megakaryocytes just as rhTPO did. AKR-501 may be useful in the treatment of patients with thrombocytopenia. Avatrombopag was first approved in 2018.

Catalog Number: I022707

CAS Number: 677007-74-8

Molecular Formula: C33H38Cl2N6O7S2

Molecular Weight:765.72

Purity: 98.0%

Appearance:Solid powder

* For research use only. Not for human or veterinary use.


SynonymsAKR501; AKR 501; AKR-501; YM477; YM-477; YM 477; AS 1670542; AS1670542; AS-1670542; E5501; E-5501; E 5501; Avatrombopag; Avatrombopag maleate.


Molecular Formula: C33H38Cl2N6O7S2
Molecular Weight765.72
SolubilitySoluble in DMSO
StorageDry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Computed Descriptor

IUPAC Name4-Piperidinecarboxylic acid, 1-(3-chloro-5-(((4-(4-chloro-2-thienyl)-5-(4-cyclohexyl-1- piperazinyl)-2-thiazolyl)amino)carbonyl)-2-pyridinyl)-, (2Z)-2-butenedioate (1:1)