For research use only. Not for therapeutic Use.
Avatrombopag hydrochloride（Cat No.:I044559）is the salt form of avatrombopag, an oral thrombopoietin receptor agonist (TPO-RA) used to treat thrombocytopenia in patients with chronic liver disease or chronic immune thrombocytopenia (ITP). It stimulates the TPO receptor (c-Mpl) on megakaryocyte precursors, promoting platelet production without directly affecting the bone marrow. Avatrombopag hydrochloride offers a convenient oral alternative to injectable TPO-RAs and has demonstrated efficacy in raising platelet counts with a favorable safety profile. Its targeted mechanism helps reduce the need for platelet transfusions before invasive procedures and supports long-term thrombocytopenia management.
| CAS Number | 570403-17-7 |
| Synonyms | 1-[3-chloro-5-[[4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)-1,3-thiazol-2-yl]carbamoyl]pyridin-2-yl]piperidine-4-carboxylic acid;hydrochloride |
| Molecular Formula | C29H35Cl3N6O3S2 |
| Purity | ≥95% |
| IUPAC Name | 1-[3-chloro-5-[[4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)-1,3-thiazol-2-yl]carbamoyl]pyridin-2-yl]piperidine-4-carboxylic acid;hydrochloride |
| InChI | InChI=1S/C29H34Cl2N6O3S2.ClH/c30-20-15-23(41-17-20)24-27(37-12-10-35(11-13-37)21-4-2-1-3-5-21)42-29(33-24)34-26(38)19-14-22(31)25(32-16-19)36-8-6-18(7-9-36)28(39)40;/h14-18,21H,1-13H2,(H,39,40)(H,33,34,38);1H |
| InChIKey | JSHJSCRYBTVFTI-UHFFFAOYSA-N |
| SMILES | C1CCC(CC1)N2CCN(CC2)C3=C(N=C(S3)NC(=O)C4=CC(=C(N=C4)N5CCC(CC5)C(=O)O)Cl)C6=CC(=CS6)Cl.Cl |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
