For research use only. Not for therapeutic Use.
Autotaxin-IN-3(CAT: I017537) is a potent and selective small-molecule inhibitor of autotaxin (ATX/ENPP2), the enzyme responsible for producing lysophosphatidic acid (LPA), a key mediator in cell proliferation, migration, and survival. By targeting the ATX–LPA signaling axis, Autotaxin-IN-3 effectively reduces LPA levels and downstream signaling events. This compound serves as a valuable research tool for exploring cancer, fibrosis, inflammation, and metabolic disorders where dysregulated ATX activity is implicated. Its inhibitory profile provides insights into the therapeutic potential of ATX blockade in modulating disease progression. Autotaxin-IN-3 is well-suited for use in biochemical, cellular, and in vivo studies of LPA biology.
| CAS Number | 2156655-68-2 |
| Synonyms | 2-[5-[2-(2,3-dihydro-1H-inden-2-ylamino)pyrimidin-5-yl]-1,3,4-oxadiazol-2-yl]-1-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)ethanone |
| Molecular Formula | C22H21N9O2 |
| Purity | ≥95% |
| IUPAC Name | 2-[5-[2-(2,3-dihydro-1H-inden-2-ylamino)pyrimidin-5-yl]-1,3,4-oxadiazol-2-yl]-1-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)ethanone |
| InChI | InChI=1S/C22H21N9O2/c32-20(31-6-5-17-18(12-31)27-30-26-17)9-19-28-29-21(33-19)15-10-23-22(24-11-15)25-16-7-13-3-1-2-4-14(13)8-16/h1-4,10-11,16H,5-9,12H2,(H,23,24,25)(H,26,27,30) |
| InChIKey | YJLUBHOZZTYQIP-UHFFFAOYSA-N |
| SMILES | C1CN(CC2=NNN=C21)C(=O)CC3=NN=C(O3)C4=CN=C(N=C4)NC5CC6=CC=CC=C6C5 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
