For research use only. Not for therapeutic Use.
AUTAC4（Cat No.:I044558）is a small-molecule autophagy-targeting chimera (AUTAC) designed to induce selective degradation of target proteins via the autophagy-lysosome pathway. It consists of a ligand that binds to a specific protein of interest linked to a degradation tag that triggers K63-linked polyubiquitination, marking the protein for autophagic clearance. AUTAC4 exemplifies a novel therapeutic strategy that leverages the cell’s natural degradation machinery to eliminate pathogenic or dysfunctional proteins. This approach is particularly valuable for targeting proteins that are resistant to proteasomal degradation, offering potential in neurodegenerative diseases and cancer therapy.
| CAS Number | 2267315-04-6 |
| Synonyms | (2R)-2-acetamido-3-[[2-amino-9-[(4-fluorophenyl)methyl]-6-oxo-1H-purin-8-yl]sulfanyl]-N-[3-[2-[2-[3-[[2-oxo-2-(2-phenyl-1H-indol-3-yl)acetyl]amino]propoxy]ethoxy]ethoxy]propyl]propanamide |
| Molecular Formula | C43H48FN9O8S |
| Purity | ≥95% |
| IUPAC Name | (2R)-2-acetamido-3-[[2-amino-9-[(4-fluorophenyl)methyl]-6-oxo-1H-purin-8-yl]sulfanyl]-N-[3-[2-[2-[3-[[2-oxo-2-(2-phenyl-1H-indol-3-yl)acetyl]amino]propoxy]ethoxy]ethoxy]propyl]propanamide |
| InChI | InChI=1S/C43H48FN9O8S/c1-27(54)48-33(26-62-43-50-36-38(51-42(45)52-40(36)57)53(43)25-28-13-15-30(44)16-14-28)39(56)46-17-7-19-59-21-23-61-24-22-60-20-8-18-47-41(58)37(55)34-31-11-5-6-12-32(31)49-35(34)29-9-3-2-4-10-29/h2-6,9-16,33,49H,7-8,17-26H2,1H3,(H,46,56)(H,47,58)(H,48,54)(H3,45,51,52,57)/t33-/m0/s1 |
| InChIKey | IYRHHSZRPVKBSQ-XIFFEERXSA-N |
| SMILES | CC(=O)N[C@@H](CSC1=NC2=C(N1CC3=CC=C(C=C3)F)N=C(NC2=O)N)C(=O)NCCCOCCOCCOCCCNC(=O)C(=O)C4=C(NC5=CC=CC=C54)C6=CC=CC=C6 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
