AUTAC2

• CAT Number: I044171
• CAS Number: 2241669-08-7
• Molecular Formula: C61H81FN10O14S
• Molecular Weight: 1229.42
• Purity: ≥95%
• Synonyms: [(1R)-1-[3-[[4-[3-[2-[2-[3-[[(2R)-2-acetamido-3-[[2-amino-9-[(4-fluorophenyl)methyl]-6-oxo-1H-purin-8-yl]sulfanyl]propanoyl]amino]propoxy]ethoxy]ethoxy]propylamino]-4-oxobutanoyl]amino]phenyl]-3-(3,4-dimethoxyphenyl)propyl] (2S)-1-(3,3-dimethyl-2-oxopentanoyl)piperidine-2-carboxylate
• InChI: InChI=1S/C61H81FN10O14S/c1-7-61(3,4)53(76)57(79)71-28-9-8-15-46(71)58(80)86-47(22-18-40-19-23-48(81-5)49(35-40)82-6)42-13-10-14-44(36-42)67-51(75)25-24-50(74)64-26-11-29-83-31-33-85-34-32-84-30-12-27-65-55(77)45(66-39(2)73)38-87-60-68-52-54(69-59(63)70-56(52)78)72(60)37-41-16-20-43(62)21-17-41/h10,13-14,16-17,19-21,23,35-36,45-47H,7-9,11-12,15,18,22,24-34,37-38H2,1-6H3,(H,64,74)(H,65,77)(H,66,73)(H,67,75)(H3,63,69,70,78)/t45-,46-,47+/m0/s1
• InChIKey: PZCJWAJPLITJCB-YQZOKAAQSA-N
• SMILES: CCC(C)(C)C(=O)C(=O)N1CCCC[C@H]1C(=O)O[C@H](CCC2=CC(=C(C=C2)OC)OC)C3=CC(=CC=C3)NC(=O)CCC(=O)NCCCOCCOCCOCCCNC(=O)[C@H](CSC4=NC5=C(N4CC6=CC=C(C=C6)F)N=C(NC5=O)N)NC(=O)C

AUTAC2（Cat No.:I044171）is a selective autophagy-targeting chimera designed to induce the degradation of target proteins via the autophagy-lysosome pathway. As a small molecule in the AUTAC (Autophagy-Targeting Chimera) family, AUTAC2 promotes K63-linked polyubiquitination, marking proteins for selective autophagic degradation. It has been used to explore protein quality control mechanisms and investigate therapeutic strategies for diseases involving protein aggregation or dysregulated autophagy, such as neurodegenerative disorders and cancer. AUTAC2 serves as a valuable chemical tool for studying targeted autophagy and developing next-generation degraders beyond the ubiquitin-proteasome system.