AUTAC1

• CAT Number: I044172
• CAS Number: 2241669-09-8
• Molecular Formula: C44H63FN8O11S
• Molecular Weight: 931.08
• Purity: ≥95%
• Synonyms: [(3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl]-1-oxaspiro[2.5]octan-6-yl] N-[3-[2-[2-[3-[[(2R)-2-acetamido-3-[[2-amino-9-[(4-fluorophenyl)methyl]-6-oxo-1H-purin-8-yl]sulfanyl]propanoyl]amino]propoxy]ethoxy]ethoxy]propyl]carbamate
• InChI: InChI=1S/C44H63FN8O11S/c1-27(2)8-13-33-43(4,64-33)36-35(58-5)32(14-15-44(36)26-62-44)63-42(57)48-17-7-19-60-21-23-61-22-20-59-18-6-16-47-38(55)31(49-28(3)54)25-65-41-50-34-37(51-40(46)52-39(34)56)53(41)24-29-9-11-30(45)12-10-29/h8-12,31-33,35-36H,6-7,13-26H2,1-5H3,(H,47,55)(H,48,57)(H,49,54)(H3,46,51,52,56)/t31-,32+,33+,35+,36+,43-,44-/m0/s1
• InChIKey: HZYVWSXXYHBZTO-KDJNBPRZSA-N
• SMILES: CC(=CC[C@@H]1[C@@](O1)(C)[C@H]2[C@@H]([C@@H](CC[C@]23CO3)OC(=O)NCCCOCCOCCOCCCNC(=O)[C@H](CSC4=NC5=C(N4CC6=CC=C(C=C6)F)N=C(NC5=O)N)NC(=O)C)OC)C

AUTAC1（Cat No.:I044172）is the first-in-class autophagy-targeting chimera (AUTAC) designed to harness the autophagy-lysosome system for targeted protein degradation. It consists of a guanine derivative that induces K63-linked polyubiquitination and a ligand that binds the target protein, facilitating its recognition by the autophagy machinery. AUTAC1 has demonstrated the ability to degrade mitochondria and specific cytosolic proteins, offering a novel approach distinct from proteasome-targeting strategies like PROTACs. It is a powerful tool for investigating selective autophagy and holds therapeutic potential in treating diseases involving protein accumulation or mitochondrial dysfunction.