For research use only. Not for therapeutic Use.
ATWLPPR peptide(CAT: I040751) is a heptapeptide (sequence: Ala-Thr-Trp-Leu-Pro-Pro-Arg) known for its high affinity and selectivity in inhibiting vascular endothelial growth factor receptor 2 (VEGFR-2/KDR) signaling. By targeting neuropilin-1 (NRP-1), a co-receptor for VEGF, ATWLPPR disrupts VEGF-mediated angiogenesis, making it a valuable tool in cancer, ophthalmology, and cardiovascular research. This peptide is commonly used to study tumor angiogenesis, vascular permeability, and endothelial cell migration. Supplied in high purity, ATWLPPR is ideal for in vitro and in vivo applications exploring anti-angiogenic strategies and VEGF/NRP-1 pathway modulation.
| CAS Number | 272121-15-0 |
| Synonyms | (2S)-2-[[(2S)-1-[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-aminopropanoyl]amino]-3-hydroxybutanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-4-methylpentanoyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoic acid |
| Molecular Formula | C40H61N11O9 |
| Purity | ≥95% |
| IUPAC Name | (2S)-2-[[(2S)-1-[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-aminopropanoyl]amino]-3-hydroxybutanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-4-methylpentanoyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoic acid |
| InChI | InChI=1S/C40H61N11O9/c1-21(2)18-29(48-34(54)28(19-24-20-45-26-11-6-5-10-25(24)26)47-36(56)32(23(4)52)49-33(53)22(3)41)37(57)51-17-9-14-31(51)38(58)50-16-8-13-30(50)35(55)46-27(39(59)60)12-7-15-44-40(42)43/h5-6,10-11,20-23,27-32,45,52H,7-9,12-19,41H2,1-4H3,(H,46,55)(H,47,56)(H,48,54)(H,49,53)(H,59,60)(H4,42,43,44)/t22-,23+,27-,28-,29-,30-,31-,32-/m0/s1 |
| InChIKey | MKSPBYRGLCNGRC-OEMOKZHXSA-N |
| SMILES | CC(C)CC(C(=O)N1CCCC1C(=O)N2CCCC2C(=O)NC(CCCN=C(N)N)C(=O)O)NC(=O)C(CC3=CNC4=CC=CC=C43)NC(=O)C(C(C)O)NC(=O)C(C)N |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
