For research use only. Not for therapeutic Use.
ATR-IN-4（Cat No.:I045153）is a potent inhibitor of ATR kinase (ataxia telangiectasia and Rad3-related), a key regulator of the DNA damage response. It significantly suppresses the proliferation of human prostate cancer DU145 and lung cancer NCI-H460 cell lines, with IC₅₀ values of 130.9 nM and 41.33 nM, respectively. The compound has a molecular formula of C₁₈H₂₀N₈O and a molecular weight of approximately 364.4 Da. ATR-IN-4 therefore serves as a valuable tool for preclinical cancer research targeting ATR-dependent DNA repair pathways.
| CAS Number | 2574545-45-0 |
| Synonyms | (3R)-3-methyl-4-[4-(2-methylpyrazol-3-yl)-7-(1H-pyrazol-5-yl)imidazo[1,5-b]pyridazin-2-yl]morpholine |
| Molecular Formula | C18H20N8O |
| Purity | ≥95% |
| IUPAC Name | (3R)-3-methyl-4-[4-(2-methylpyrazol-3-yl)-7-(1H-pyrazol-5-yl)imidazo[1,5-b]pyridazin-2-yl]morpholine |
| InChI | InChI=1S/C18H20N8O/c1-12-11-27-8-7-25(12)17-9-13(15-4-6-21-24(15)2)16-10-19-18(26(16)23-17)14-3-5-20-22-14/h3-6,9-10,12H,7-8,11H2,1-2H3,(H,20,22)/t12-/m1/s1 |
| InChIKey | BUTVLOCHWATRAS-GFCCVEGCSA-N |
| SMILES | C[C@@H]1COCCN1C2=NN3C(=CN=C3C4=CC=NN4)C(=C2)C5=CC=NN5C |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
