ATH686（Cat No.:I045784）is a selective inhibitor of protein phosphatase 2A (PP2A), a key serine/threonine phosphatase involved in regulating cell cycle progression, apoptosis, and signal transduction. By blocking PP2A activity, ATH686 modulates phosphorylation-dependent pathways, offering insights into cancer biology and neurodegenerative processes where PP2A plays a pivotal role. It has been applied in studies exploring tumor progression, kinase–phosphatase balance, and therapeutic strategies targeting phosphatase regulation. ATH686 serves as a valuable chemical probe for dissecting PP2A-mediated signaling networks and investigating its role in disease development and potential drug discovery.