ATG7-IN-2

• CAT Number: I043689
• CAS Number: 2226227-75-2
• Molecular Formula: C11H16N6O7S
• Molecular Weight: 376.35
• Purity: ≥95%
• Synonyms: [(2R,3S,4R,5R)-5-(4-amino-3-methoxypyrazolo[3,4-d]pyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl sulfamate
• InChI: InChI=1S/C11H16N6O7S/c1-22-10-5-8(12)14-3-15-9(5)17(16-10)11-7(19)6(18)4(24-11)2-23-25(13,20)21/h3-4,6-7,11,18-19H,2H2,1H3,(H2,12,14,15)(H2,13,20,21)/t4-,6-,7-,11-/m1/s1
• InChIKey: SVHOPJCSYNTLAH-RPKMEZRRSA-N
• SMILES: COC1=NN(C2=NC=NC(=C21)N)[C@H]3[C@@H]([C@@H]([C@H](O3)COS(=O)(=O)N)O)O

ATG7-IN-2（Cat No.:I043689）is a small molecule inhibitor designed to target and block the activity of ATG7, a key protein involved in autophagy, a cellular process essential for maintaining homeostasis by degrading and recycling cellular components. By inhibiting ATG7, ATG7-IN-2 disrupts autophagy, which can impact cancer cell survival, neurodegenerative disease progression, and pathogen clearance. Preclinical studies suggest that ATG7-IN-2 could enhance the effectiveness of cancer therapies, as well as provide potential therapeutic benefits in diseases where autophagy contributes to disease progression, such as Alzheimer’s and Parkinson’s diseases.