For research use only. Not for therapeutic Use.
ATG7-IN-1（Cat No.:I045145）is a selective small-molecule inhibitor of autophagy-related protein 7 (ATG7), a key E1-like enzyme involved in the autophagy pathway. By blocking ATG7 activity, ATG7-IN-1 disrupts the conjugation of ATG12 and LC3 proteins, thereby inhibiting autophagosome formation and impairing autophagic flux. It is used to study the role of autophagy in cancer, neurodegeneration, and immune regulation. ATG7-IN-1 enables researchers to dissect ATG7-specific functions and evaluate therapeutic strategies targeting autophagy. Supplied for research into autophagy modulation, cell survival mechanisms, and lysosomal degradation pathways.
| CAS Number | 2226229-87-2 |
| Synonyms | [(2S,3S,5R)-5-[4-amino-3-(2-fluoro-4-methylphenyl)sulfanylpyrazolo[3,4-d]pyrimidin-1-yl]-3-hydroxyoxolan-2-yl]methyl sulfamate |
| Molecular Formula | C17H19FN6O5S2 |
| Purity | ≥95% |
| IUPAC Name | [(2S,3S,5R)-5-[4-amino-3-(2-fluoro-4-methylphenyl)sulfanylpyrazolo[3,4-d]pyrimidin-1-yl]-3-hydroxyoxolan-2-yl]methyl sulfamate |
| InChI | InChI=1S/C17H19FN6O5S2/c1-8-2-3-12(9(18)4-8)30-17-14-15(19)21-7-22-16(14)24(23-17)13-5-10(25)11(29-13)6-28-31(20,26)27/h2-4,7,10-11,13,25H,5-6H2,1H3,(H2,19,21,22)(H2,20,26,27)/t10-,11-,13+/m0/s1 |
| InChIKey | GRYCCRMITKNCNZ-GMXVVIOVSA-N |
| SMILES | CC1=CC(=C(C=C1)SC2=NN(C3=NC=NC(=C32)N)[C@H]4C[C@@H]([C@@H](O4)COS(=O)(=O)N)O)F |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
