For research use only. Not for therapeutic Use.
AT-9010 tetrasodium（Cat No.:I044440）is the active triphosphate metabolite of AT-527, a guanosine nucleotide analog developed as an antiviral agent, particularly against RNA viruses like SARS-CoV-2 and hepatitis C virus (HCV). As a prodrug metabolite, AT-9010 incorporates into viral RNA via the viral RNA-dependent RNA polymerase (RdRp), leading to chain termination and inhibition of viral replication. The tetrasodium salt form enhances solubility and stability for in vitro and in vivo studies. AT-9010 tetrasodium is a valuable compound in antiviral research, supporting the development of nucleotide-based therapies for RNA virus infections.
| CAS Number | 1621884-18-1 |
| Synonyms | tetrasodium;[[[(2R,3R,4R,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-4-fluoro-3-hydroxy-4-methyloxolan-2-yl]methoxy-oxidophosphoryl]oxy-oxidophosphoryl] phosphate |
| Molecular Formula | C11H13FN5Na4O13P3 |
| Purity | ≥95% |
| IUPAC Name | tetrasodium;[[[(2R,3R,4R,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-4-fluoro-3-hydroxy-4-methyloxolan-2-yl]methoxy-oxidophosphoryl]oxy-oxidophosphoryl] phosphate |
| InChI | InChI=1S/C11H17FN5O13P3.4Na/c1-11(12)6(18)4(2-27-32(23,24)30-33(25,26)29-31(20,21)22)28-9(11)17-3-14-5-7(17)15-10(13)16-8(5)19;;;;/h3-4,6,9,18H,2H2,1H3,(H,23,24)(H,25,26)(H2,20,21,22)(H3,13,15,16,19);;;;/q;4*+1/p-4/t4-,6-,9-,11-;;;;/m1..../s1 |
| InChIKey | YSFIWHKJCYGPPP-ZJECJYFYSA-J |
| SMILES | C[C@]1([C@@H]([C@H](O[C@H]1N2C=NC3=C2N=C(NC3=O)N)COP(=O)([O-])OP(=O)([O-])OP(=O)([O-])[O-])O)F.[Na+].[Na+].[Na+].[Na+] |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
