For research use only. Not for therapeutic Use.
AST5902 Trimesylate（Cat No.:I044595）is an investigational small-molecule inhibitor targeting the bromodomain and extraterminal (BET) family of proteins, particularly BRD4, which regulates genes involved in inflammation, fibrosis, and oncogenesis. As a tris-mesylate salt form, it enhances the compound’s solubility and stability for therapeutic use. AST5902 promotes transcriptional repression of pro-inflammatory and profibrotic genes, showing potential in treating diseases such as idiopathic pulmonary fibrosis (IPF) and certain cancers. Preclinical studies demonstrate that AST5902 Trimesylate effectively modulates gene expression and inhibits disease progression, supporting its development as a targeted epigenetic therapy.
| CAS Number | 2929417-90-1 |
| Synonyms | methanesulfonic acid;N-[5-[[4-(1-methylindol-3-yl)pyrimidin-2-yl]amino]-2-[methyl-[2-(methylamino)ethyl]amino]-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]prop-2-enamide |
| Molecular Formula | C30H41F3N8O11S3 |
| Purity | ≥95% |
| IUPAC Name | methanesulfonic acid;N-[5-[[4-(1-methylindol-3-yl)pyrimidin-2-yl]amino]-2-[methyl-[2-(methylamino)ethyl]amino]-6-(2,2,2-trifluoroethoxy)pyridin-3-yl]prop-2-enamide |
| InChI | InChI=1S/C27H29F3N8O2.3CH4O3S/c1-5-23(39)33-20-14-21(25(40-16-27(28,29)30)36-24(20)37(3)13-12-31-2)35-26-32-11-10-19(34-26)18-15-38(4)22-9-7-6-8-17(18)22;3*1-5(2,3)4/h5-11,14-15,31H,1,12-13,16H2,2-4H3,(H,33,39)(H,32,34,35);3*1H3,(H,2,3,4) |
| InChIKey | KRCDPFVVSHJNOV-UHFFFAOYSA-N |
| SMILES | CNCCN(C)C1=NC(=C(C=C1NC(=O)C=C)NC2=NC=CC(=N2)C3=CN(C4=CC=CC=C43)C)OCC(F)(F)F.CS(=O)(=O)O.CS(=O)(=O)O.CS(=O)(=O)O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
