ASR-490

• CAT Number: I044024
• CAS Number: 2690312-67-3
• Molecular Formula: C34H41NO7
• Molecular Weight: 575.69
• Purity: ≥95%
• Synonyms: [(2R,6S,7S,9R,15R,16S)-15-[(1S)-1-[(2R)-5-(hydroxymethyl)-4-methyl-6-oxo-2,3-dihydropyran-2-yl]ethyl]-2,16-dimethyl-3-oxo-8-oxapentacyclo[9.7.0.02,7.07,9.012,16]octadec-4-en-6-yl] pyridine-2-carboxylate
• IUPAC Name: [(1S,2R,6S,7S,9R,11S,12S,15R,16S)-15-[(1S)-1-[(2R)-5-(hydroxymethyl)-4-methyl-6-oxo-2,3-dihydropyran-2-yl]ethyl]-2,16-dimethyl-3-oxo-8-oxapentacyclo[9.7.0.02,7.07,9.012,16]octadec-4-en-6-yl] pyridine-2-carboxylate
• InChI: InChI=1S/C34H41NO7/c1-18-15-26(40-30(38)21(18)17-36)19(2)22-8-9-23-20-16-29-34(42-29)28(41-31(39)25-7-5-6-14-35-25)11-10-27(37)33(34,4)24(20)12-13-32(22,23)3/h5-7,10-11,14,19-20,22-24,26,28-29,36H,8-9,12-13,15-17H2,1-4H3/t19-,20-,22+,23-,24-,26+,28-,29+,32+,33-,34+/m0/s1
• InChIKey: VLOZRPFAQLWDLI-RJMVMCCISA-N
• SMILES: CC1=C(C(=O)O[C@H](C1)[C@@H](C)[C@H]2CC[C@@H]3[C@@]2(CC[C@H]4[C@H]3C[C@@H]5[C@]6([C@@]4(C(=O)C=C[C@@H]6OC(=O)C7=CC=CC=N7)C)O5)C)CO

ASR-490（Cat No.:I044024）is a potent and selective non-peptidic antagonist of activin receptor-like kinase 5 (ALK5), a receptor for transforming growth factor-beta (TGF-β). By inhibiting ALK5, ASR-490 effectively blocks TGF-β signaling, which plays a pivotal role in fibrosis, cancer progression, and immune regulation. This compound is especially valuable in preclinical studies focused on fibrotic diseases, epithelial-mesenchymal transition (EMT), and tumor microenvironment modulation. Its non-peptidic structure offers enhanced stability and bioavailability compared to peptide-based inhibitors, making ASR-490 a promising research tool in therapeutic development targeting the TGF-β/ALK5 pathway.