ASP-4058 hydrochloride

• CAT Number: I022531
• CAS Number: 952510-14-4
• Molecular Formula: C19H13ClF6N4O2
• Molecular Weight: 478.78
• Purity: ≥95%
• Synonyms: 3-(3H-benzimidazol-5-yl)-5-[3-(trifluoromethyl)-4-[(2S)-1,1,1-trifluoropropan-2-yl]oxyphenyl]-1,2,4-oxadiazole;hydrochloride
• InChI: InChI=1S/C19H12F6N4O2.ClH/c1-9(18(20,21)22)30-15-5-3-11(6-12(15)19(23,24)25)17-28-16(29-31-17)10-2-4-13-14(7-10)27-8-26-13;/h2-9H,1H3,(H,26,27);1H/t9-;/m0./s1
• InChIKey: KRUYZACYZSOZCV-FVGYRXGTSA-N
• SMILES: CC(C(F)(F)F)OC1=C(C=C(C=C1)C2=NC(=NO2)C3=CC4=C(C=C3)N=CN4)C(F)(F)F.Cl

ASP-4058 hydrochloride (Cat No.: I022531) is a selective sphingosine-1-phosphate receptor 1 (S1P1) agonist developed as a research tool for studying vascular biology and immune modulation. By activating S1P1, it influences endothelial barrier function, lymphocyte trafficking, and vascular stability. Researchers use ASP-4058 hydrochloride to investigate therapeutic strategies for autoimmune diseases, inflammation, and vascular disorders. Its receptor selectivity makes it valuable for distinguishing S1P1-specific effects from other S1P receptor subtypes. Although not approved for clinical application, it serves as an important compound in pharmacological and biomedical research.

Reference

[1]. Rie Yamamoto, et al. ASP4058, a Novel Agonist for Sphingosine 1-Phosphate Receptors 1 and 5, Ameliorates Rodent Experimental Autoimmune Encephalomyelitis with a Favorable Safety Profile. PLoS One. 2014 Oct 27;9(10):e110819.
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