For research use only. Not for therapeutic Use.
ASN007（Cat No.:I014894）is an orally active, selective inhibitor of extracellular signal-regulated kinases 1 and 2 (ERK1/2), key components of the RAS/RAF/MEK/ERK signaling cascade. By blocking ERK activity, ASN007 disrupts tumor cell proliferation, survival, and resistance mechanisms driven by aberrant MAPK pathway signaling. Preclinical studies have shown potent antitumor efficacy across various RAS- and BRAF-mutant cancers, including melanoma and colorectal carcinoma. ASN007 is under clinical investigation as a promising targeted therapy, making it a valuable tool in oncology research for exploring MAPK-driven malignancies and combination treatment strategies.
| CAS Number | 2055597-12-9 |
| Synonyms | N-[(1S)-2-amino-1-(3-chloro-5-fluorophenyl)ethyl]-1-[5-methyl-2-(oxan-4-ylamino)pyrimidin-4-yl]imidazole-4-carboxamide |
| Molecular Formula | C22H25ClFN7O2 |
| Purity | ≥95% |
| IUPAC Name | N-[(1S)-2-amino-1-(3-chloro-5-fluorophenyl)ethyl]-1-[5-methyl-2-(oxan-4-ylamino)pyrimidin-4-yl]imidazole-4-carboxamide |
| InChI | InChI=1S/C22H25ClFN7O2/c1-13-10-26-22(28-17-2-4-33-5-3-17)30-20(13)31-11-19(27-12-31)21(32)29-18(9-25)14-6-15(23)8-16(24)7-14/h6-8,10-12,17-18H,2-5,9,25H2,1H3,(H,29,32)(H,26,28,30)/t18-/m1/s1 |
| InChIKey | PWHIUQBBGPGFFV-GOSISDBHSA-N |
| SMILES | CC1=CN=C(N=C1N2C=C(N=C2)C(=O)N[C@H](CN)C3=CC(=CC(=C3)Cl)F)NC4CCOCC4 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
