For research use only. Not for therapeutic Use.
ASN007 benzenesulfonate（Cat No.:I044492）is the salt form of ASN007, a selective, orally bioavailable inhibitor of extracellular signal-regulated kinase 1 and 2 (ERK1/2), key components of the MAPK signaling pathway. This pathway is frequently dysregulated in cancers with RAS or BRAF mutations. ASN007 inhibits ERK-mediated transcription and proliferation, offering therapeutic potential in resistant tumors where upstream inhibitors fail. The benzenesulfonate salt enhances its solubility and stability for improved pharmacokinetics. ASN007 is currently under investigation in preclinical and clinical studies targeting solid tumors and hematologic malignancies driven by MAPK pathway activation.
| CAS Number | 2055597-39-0 |
| Synonyms | N-[(1S)-2-amino-1-(3-chloro-5-fluorophenyl)ethyl]-1-[5-methyl-2-(oxan-4-ylamino)pyrimidin-4-yl]imidazole-4-carboxamide;benzenesulfonic acid |
| Molecular Formula | C28H31ClFN7O5S |
| Purity | ≥95% |
| IUPAC Name | N-[(1S)-2-amino-1-(3-chloro-5-fluorophenyl)ethyl]-1-[5-methyl-2-(oxan-4-ylamino)pyrimidin-4-yl]imidazole-4-carboxamide;benzenesulfonic acid |
| InChI | InChI=1S/C22H25ClFN7O2.C6H6O3S/c1-13-10-26-22(28-17-2-4-33-5-3-17)30-20(13)31-11-19(27-12-31)21(32)29-18(9-25)14-6-15(23)8-16(24)7-14;7-10(8,9)6-4-2-1-3-5-6/h6-8,10-12,17-18H,2-5,9,25H2,1H3,(H,29,32)(H,26,28,30);1-5H,(H,7,8,9)/t18-;/m1./s1 |
| InChIKey | JXWBNMQMMAONIH-GMUIIQOCSA-N |
| SMILES | CC1=CN=C(N=C1N2C=C(N=C2)C(=O)N[C@H](CN)C3=CC(=CC(=C3)Cl)F)NC4CCOCC4.C1=CC=C(C=C1)S(=O)(=O)O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
