ASK1-IN-2

• CAT Number: I045428
• CAS Number: 2541792-70-3
• Molecular Formula: C19H17FN6O
• Molecular Weight: 364.38
• Purity: ≥95%
• Synonyms: 6-fluoro-N-[6-(4-propan-2-yl-1,2,4-triazol-3-yl)pyridin-2-yl]-1H-indole-2-carboxamide
• InChI: InChI=1S/C19H17FN6O/c1-11(2)26-10-21-25-18(26)14-4-3-5-17(23-14)24-19(27)16-8-12-6-7-13(20)9-15(12)22-16/h3-11,22H,1-2H3,(H,23,24,27)
• InChIKey: LYUQNMNUBOUCBX-UHFFFAOYSA-N
• SMILES: CC(C)N1C=NN=C1C2=NC(=CC=C2)NC(=O)C3=CC4=C(N3)C=C(C=C4)F

ASK1-IN-2 (Cat No.: I045428) is a potent, selective inhibitor of apoptosis signal-regulating kinase 1 (ASK1), a MAP kinase kinase kinase (MAP3K) that activates the p38 and JNK signaling pathways in response to oxidative and endoplasmic reticulum stress. By blocking ASK1 activity, ASK1-IN-2 reduces downstream pro-apoptotic and pro-inflammatory signaling, offering potential therapeutic benefits in conditions such as neurodegenerative diseases, cardiovascular disorders, and fibrosis. It is widely used in research to investigate ASK1-mediated stress responses, cell death regulation, and the development of targeted treatments for stress-related pathologies.

Reference

[1]. Hou S, et, al. Structure-based discovery of 1H-indole-2-carboxamide derivatives as potent ASK1 inhibitors for potential treatment of ulcerative colitis. Eur J Med Chem. 2020 Dec 24;211:113114.
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