For research use only. Not for therapeutic Use.
ASK1-IN-1（Cat No.:I045873）is a potent and selective inhibitor of apoptosis signal-regulating kinase 1 (ASK1), a MAP kinase kinase kinase (MAP3K) that mediates stress-induced apoptosis and inflammation through the JNK and p38 signaling pathways. By suppressing ASK1 activation, this compound reduces oxidative stress–induced cell death and inflammatory responses, making it a valuable tool for studying redox biology and stress signaling. ASK1-IN-1 is widely used in research on cardiovascular diseases, neurodegeneration, and fibrosis, where ASK1 dysregulation contributes to pathology. Its specificity provides therapeutic potential in targeted drug discovery.
| CAS Number | 2411382-24-4 |
| Synonyms | 3-methoxy-N-[6-(4-propan-2-yl-1,2,4-triazol-3-yl)pyridin-2-yl]-1-pyrazin-2-ylpyrazole-4-carboxamide |
| Molecular Formula | C19H19N9O2 |
| Purity | ≥95% |
| IUPAC Name | 3-methoxy-N-[6-(4-propan-2-yl-1,2,4-triazol-3-yl)pyridin-2-yl]-1-pyrazin-2-ylpyrazole-4-carboxamide |
| InChI | InChI=1S/C19H19N9O2/c1-12(2)27-11-22-25-17(27)14-5-4-6-15(23-14)24-18(29)13-10-28(26-19(13)30-3)16-9-20-7-8-21-16/h4-12H,1-3H3,(H,23,24,29) |
| InChIKey | FTPVMITWJIXRGQ-UHFFFAOYSA-N |
| SMILES | CC(C)N1C=NN=C1C2=NC(=CC=C2)NC(=O)C3=CN(N=C3OC)C4=NC=CN=C4 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
