Asiatic Acid

  • CAT Number: R039716
  • CAS Number: 464-92-6
  • Molecular Formula: C30H48O5
  • Molecular Weight: 488.7
  • Purity: ≥95%
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Asiatic Acid(CAT: R039716) is a pentacyclic triterpene isolated from a variety of plants, including those used in traditional medicine. It has certain anti-inflammatory effects and can also block the generation of tumor cells and tumor blood vessels by inducing cell cycle arrest and apoptosis of tumor cells. This product is used for medical research and development.

Catalog Number R039716
CAS Number 464-92-6
Synonyms

2a,3β,23-Trihydroxyurs-12-en-28-oic Acid; 2α,23-Dihydroxyursolic Acid; 2α,3β,19,23-Tetrahydroxy-urs-12-en-28-oic Acid; 2α,3β,23-Trihydroxyurs-12-en-28-oic Acid; Dammarolic Acid; NSC 166063

Molecular Formula

C30H48O5

Purity 95%
Storage 3 years -20C powder
IUPAC Name (1S,2R,4aS,6aR,6aS,6bR,8aR,9R,10R,11R,12aR,14bS)-10,11-dihydroxy-9-(hydroxymethyl)-1,2,6a,6b,9,12a-hexamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydro-1H-picene-4a-carboxylic acid
InChI InChI=1S/C30H48O5/c1-17-9-12-30(25(34)35)14-13-28(5)19(23(30)18(17)2)7-8-22-26(3)15-20(32)24(33)27(4,16-31)21(26)10-11-29(22,28)6/h7,17-18,20-24,31-33H,8-16H2,1-6H3,(H,34,35)/t17-,18+,20-,21-,22-,23+,24+,26+,27+,28-,29-,30+/m1/s1
InChIKey JXSVIVRDWWRQRT-DPJHZOGISA-N
SMILES OC[C@]1(C)[C@@H](O)[C@H](O)C[C@@]2(C)[C@@]1([H])CC[C@]3(C)[C@]2([H])CC=C4[C@@]3(C)CC[C@]5(C(O)=O)[C@@]4([H])[C@@H](C)[C@H](C)CC5
Reference

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1:ASIATIC ACID INFLUENCES GLUCOSE HOMEOSTASIS IN <i>P. BERGHEI</i> MURINE MALARIA INFECTED SPRAGUE-DAWLEY RATS. Alfred MG, Nkazimulo MB, Vuyisile MM, Tagumirwa MC.Afr J Tradit Complement Altern Med. 2016 Aug 12;13(5):91-101. doi: 10.21010/ajtcam.v13i5.13. eCollection 2016. PMID: 28487899<br />
2:Retraction of /Antioxidative and Antiinflammatory Activities of Asiatic Acid, Glycyrrhizic Acid, and Oleanolic Acid in Human Bronchial Epithelial Cells/. Tsao SM, Yin MC.J Agric Food Chem. 2017 Apr 19;65(15):3251. doi: 10.1021/acs.jafc.7b01473. Epub 2017 Apr 6. No abstract available. PMID: 28381084<br />
3:Asiatic acid ameliorates pulmonary fibrosis induced by bleomycin (BLM) via suppressing pro-fibrotic and inflammatory signaling pathways. Dong SH, Liu YW, Wei F, Tan HZ, Han ZD.Biomed Pharmacother. 2017 May;89:1297-1309. doi: 10.1016/j.biopha.2017.03.005. Epub 2017 Mar 17. PMID: 28320097<br />
4:The anti-inflammatory effects of asiatic acid in lipopolysaccharide-stimulated human corneal epithelial cells. Chen H, Hua XM, Ze BC, Wang B, Wei L.Int J Ophthalmol. 2017 Feb 18;10(2):179-185. doi: 10.18240/ijo.2017.02.01. eCollection 2017. PMID: 28251074 Free PMC Article<br />
5:Pharmacological effects of asiatic acid in glioblastoma cells under hypoxia. Thakor FK, Wan KW, Welsby PJ, Welsby G.Mol Cell Biochem. 2017 Jun;430(1-2):179-190. doi: 10.1007/s11010-017-2965-5. Epub 2017 Feb 15. PMID: 28205096<br />
6:Neurotrophic Effect of Asiatic acid, a Triterpene of Centella asiatica Against Chronic 1-Methyl 4-Phenyl 1, 2, 3, 6-Tetrahydropyridine Hydrochloride/Probenecid Mouse Model of Parkinson/&#39;s disease: The Role of MAPK, PI3K-Akt-GSK3&beta; and mTOR Signalling Pathways. Nataraj J, Manivasagam T, Justin Thenmozhi A, Essa MM.Neurochem Res. 2017 May;42(5):1354-1365. doi: 10.1007/s11064-017-2183-2. Epub 2017 Feb 8. PMID: 28181071<br />
7:Asiatic acid inhibits lung cancer cell growth <i>in vitro</i> and <i>in vivo</i> by destroying mitochondria. Wu T, Geng J, Guo W, Gao J, Zhu X.Acta Pharm Sin B. 2017 Jan;7(1):65-72. doi: 10.1016/j.apsb.2016.04.003. Epub 2016 Jun 20. PMID: 28119810 Free PMC Article<br />
8:Asiatic acid enhances Nrf2 signaling to protect HepG2 cells from oxidative damage through Akt and ERK activation. Qi Z, Ci X, Huang J, Liu Q, Yu Q, Zhou J, Deng X.Biomed Pharmacother. 2017 Apr;88:252-259. doi: 10.1016/j.biopha.2017.01.067. Epub 2017 Jan 19. PMID: 28110191<br />
9:A novel synthetic Asiatic acid derivative induces apoptosis and inhibits proliferation and mobility of gastric cancer cells by suppressing STAT3 signaling pathway. Wang G, Jing Y, Cao L, Gong C, Gong Z, Cao X.Onco Targets Ther. 2016 Dec 20;10:55-66. doi: 10.2147/OTT.S121619. eCollection 2017. PMID: 28053540 Free PMC Article<br />
10:Asiatic acid attenuates pre-neoplastic lesions, oxidative stress, biotransforming enzymes and histopathological alterations in 1,2-dimethylhydrazine-induced experimental rat colon carcinogenesis. Siddique AI, Mani V, Arivalagan S, Thomas NS, Namasivayam N.Toxicol Mech Methods. 2017 Feb;27(2):136-150. doi: 10.1080/15376516.2016.1273422. Epub 2017 Jan 11. PMID: 28004603

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