For research use only. Not for therapeutic Use.
AS2444697（Cat No.:I011192）is a potent, selective sphingosine-1-phosphate 2 (S1P₂) receptor antagonist. By blocking S1P₂-mediated signaling, it reduces vascular inflammation, endothelial dysfunction, and fibrosis. Preclinical studies suggest that AS2444697 may benefit cardiovascular disease, pulmonary hypertension, and fibrotic disorders by improving vascular tone and limiting pathological remodeling. Its high receptor selectivity makes it valuable for probing S1P biology and distinguishing S1P₂-specific pathways from other S1P receptor subtypes. AS2444697 serves as both a pharmacological research tool and a potential therapeutic lead for vascular and fibrotic disease research.
| CAS Number | 1287665-60-4 |
| Synonyms | N-[3-carbamoyl-1-(oxan-4-yl)pyrazol-4-yl]-2-(2-methylpyridin-4-yl)-1,3-oxazole-4-carboxamide;hydrochloride |
| Molecular Formula | C19H21ClN6O4 |
| Purity | ≥95% |
| IUPAC Name | N-[3-carbamoyl-1-(oxan-4-yl)pyrazol-4-yl]-2-(2-methylpyridin-4-yl)-1,3-oxazole-4-carboxamide;hydrochloride |
| InChI | InChI=1S/C19H20N6O4.ClH/c1-11-8-12(2-5-21-11)19-23-15(10-29-19)18(27)22-14-9-25(24-16(14)17(20)26)13-3-6-28-7-4-13;/h2,5,8-10,13H,3-4,6-7H2,1H3,(H2,20,26)(H,22,27);1H |
| InChIKey | FGNHLIIFEDYNFZ-UHFFFAOYSA-N |
| SMILES | CC1=NC=CC(=C1)C2=NC(=CO2)C(=O)NC3=CN(N=C3C(=O)N)C4CCOCC4.Cl |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
