For research use only. Not for therapeutic Use.
AS19(CAT: I010482) is a potent and highly selective 5-HT₇ receptor agonist with an IC₅₀ of 0.83 nM and a Ki of 0.6 nM. It demonstrates strong selectivity over related serotonin receptors, including 5-HT₁A, 5-HT₁B, 5-HT₁D, and 5-HT₅A. Preclinical studies show that AS19 enhances memory consolidation and reverses amnesia induced by scopolamine or dizocilpine. In immune models, AS19 restores T-cell proliferation suppressed by serotonin depletion. In vivo, subcutaneous administration (0.5–10 mg/kg) improves performance in learning and memory tasks. With dual cognitive and immunomodulatory effects, AS19 is a valuable tool for neuroscience, psychopharmacology, and serotonin receptor research.
| CAS Number | 1000578-26-6 |
| Synonyms | (2S)-N,N-dimethyl-5-(1,3,5-trimethylpyrazol-4-yl)-1,2,3,4-tetrahydronaphthalen-2-amine |
| Molecular Formula | C18H25N3 |
| Purity | ≥95% |
| IUPAC Name | (2S)-N,N-dimethyl-5-(1,3,5-trimethylpyrazol-4-yl)-1,2,3,4-tetrahydronaphthalen-2-amine |
| InChI | InChI=1S/C18H25N3/c1-12-18(13(2)21(5)19-12)17-8-6-7-14-11-15(20(3)4)9-10-16(14)17/h6-8,15H,9-11H2,1-5H3/t15-/m0/s1 |
| InChIKey | BTTOYOKCLDAHHO-HNNXBMFYSA-N |
| SMILES | CC1=C(C(=NN1C)C)C2=CC=CC3=C2CCC(C3)N(C)C |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
