For research use only. Not for therapeutic Use.
AS1892802（Cat No.:R061893）is a potent and selective inhibitor of Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4), an upstream kinase involved in inflammatory signaling, insulin resistance, and cancer progression. By targeting MAP4K4, AS1892802 suppresses downstream JNK pathway activation, reducing pro-inflammatory cytokine production and improving insulin signaling. It is widely used in preclinical studies to explore therapeutic strategies for metabolic disorders such as type 2 diabetes, as well as inflammatory and oncological conditions. AS1892802 serves as a valuable tool for dissecting MAP4K4-mediated pathways and developing kinase-targeted interventions.
| CAS Number | 928320-12-1 |
| Synonyms | 1-[(1S)-2-hydroxy-1-phenylethyl]-3-(4-pyridin-4-ylphenyl)urea |
| Molecular Formula | C20H19N3O2 |
| Purity | ≥95% |
| IUPAC Name | 1-[(1S)-2-hydroxy-1-phenylethyl]-3-(4-pyridin-4-ylphenyl)urea |
| InChI | InChI=1S/C20H19N3O2/c24-14-19(17-4-2-1-3-5-17)23-20(25)22-18-8-6-15(7-9-18)16-10-12-21-13-11-16/h1-13,19,24H,14H2,(H2,22,23,25)/t19-/m1/s1 |
| InChIKey | WDTFYYZHMRBVHK-LJQANCHMSA-N |
| SMILES | C1=CC=C(C=C1)[C@@H](CO)NC(=O)NC2=CC=C(C=C2)C3=CC=NC=C3 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
