For research use only. Not for therapeutic Use.
AS1810722（Cat No.:I044543）is a selective and potent inhibitor of retinoic acid–related orphan receptor gamma t (RORγt), a key transcription factor regulating Th17 cell differentiation and IL-17 cytokine production. By inhibiting RORγt, AS1810722 suppresses the expression of pro-inflammatory cytokines, making it a promising candidate for treating autoimmune and inflammatory diseases such as psoriasis, rheumatoid arthritis, and multiple sclerosis. Preclinical studies have demonstrated its efficacy in reducing Th17-mediated inflammation without broadly suppressing the immune system. AS1810722 offers a targeted approach to modulating immune responses by specifically blocking the RORγt signaling axis.
| CAS Number | 909561-15-5 |
| Synonyms | 2-[4-[4-[[7-[(3,5-difluorophenyl)methyl]pyrrolo[2,3-d]pyrimidin-2-yl]amino]phenyl]piperazin-1-yl]acetamide |
| Molecular Formula | C25H25F2N7O |
| Purity | ≥95% |
| IUPAC Name | 2-[4-[4-[[7-[(3,5-difluorophenyl)methyl]pyrrolo[2,3-d]pyrimidin-2-yl]amino]phenyl]piperazin-1-yl]acetamide |
| InChI | InChI=1S/C25H25F2N7O/c26-19-11-17(12-20(27)13-19)15-34-6-5-18-14-29-25(31-24(18)34)30-21-1-3-22(4-2-21)33-9-7-32(8-10-33)16-23(28)35/h1-6,11-14H,7-10,15-16H2,(H2,28,35)(H,29,30,31) |
| InChIKey | IJFRMEXSGYTWGY-UHFFFAOYSA-N |
| SMILES | C1CN(CCN1CC(=O)N)C2=CC=C(C=C2)NC3=NC=C4C=CN(C4=N3)CC5=CC(=CC(=C5)F)F |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
