AS-041164

• CAT Number: I011739
• CAS Number: 6318-41-8
• Molecular Formula: C11H7NO4S
• Molecular Weight: 249.24
• Purity: ≥95%
• Synonyms: (5Z)-5-(1,3-benzodioxol-5-ylmethylidene)-1,3-thiazolidine-2,4-dione
• InChI: InChI=1S/C11H7NO4S/c13-10-9(17-11(14)12-10)4-6-1-2-7-8(3-6)16-5-15-7/h1-4H,5H2,(H,12,13,14)/b9-4-
• InChIKey: SDGWAUUPHUBJNQ-WTKPLQERSA-N
• SMILES: C1OC2=C(O1)C=C(C=C2)C=C3C(=O)NC(=O)S3

AS-041164 (Cat No.: I011739) is a small-molecule inhibitor identified for its ability to block the activity of IRE1α (inositol-requiring enzyme 1 alpha), a critical sensor in the unfolded protein response (UPR) pathway. By targeting IRE1α’s endoribonuclease activity, AS-041164 prevents XBP1 mRNA splicing and downstream stress signaling, thereby modulating cellular adaptation to endoplasmic reticulum stress. It is used in research to explore ER stress, apoptosis, cancer biology, and metabolic disease mechanisms, serving as a valuable tool for drug discovery and therapeutic strategy development.

Reference

[1]. Chiara Ferrandi, et al. Phosphoinositide 3-kinase gamma inhibition plays a crucial role in early steps of inflammation by blocking neutrophil recruitment. J Pharmacol Exp Ther. 2007 Sep;322(3):923-30.
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