For research use only. Not for therapeutic Use.
ARUK2007145(CAT: I040306) is a potent, cell-permeable dual inhibitor targeting the phosphatidylinositol-5-phosphate 4-kinase isoforms PI5P4Kα and PI5P4Kγ, with pIC₅₀ values of 7.3 and 8.1, respectively. These lipid kinases regulate intracellular phosphoinositide signaling involved in metabolism, autophagy, and immune response. By selectively inhibiting PI5P4Kα/γ, ARUK2007145 disrupts key pathways implicated in cancer, neurodegeneration, and inflammatory diseases. Its high potency and cellular activity make it a valuable chemical probe for elucidating PI5P4K functions and validating therapeutic targets. ARUK2007145 is ideal for preclinical studies investigating phosphoinositide signaling modulation.
| Synonyms | 6-(2-chloropyridin-3-yl)-N-(4-methylsulfanylphenyl)thieno[3,2-d]pyrimidin-4-amine |
| Molecular Formula | C18H13ClN4S2 |
| Purity | ≥95% |
| IUPAC Name | 6-(2-chloropyridin-3-yl)-N-(4-methylsulfanylphenyl)thieno[3,2-d]pyrimidin-4-amine |
| InChI | InChI=1S/C18H13ClN4S2/c1-24-12-6-4-11(5-7-12)23-18-16-14(21-10-22-18)9-15(25-16)13-3-2-8-20-17(13)19/h2-10H,1H3,(H,21,22,23) |
| InChIKey | YGLJUHZYDURHAF-UHFFFAOYSA-N |
| SMILES | CSC1=CC=C(C=C1)NC2=NC=NC3=C2SC(=C3)C4=C(N=CC=C4)Cl |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
