ARUK2001607

• CAT Number: I042358
• CAS Number: 2924824-56-4
• Molecular Formula: C14H13N3O2S2
• Molecular Weight: 319.40
• Purity: ≥95%
• Synonyms: 6-methyl-N-(4-methylsulfonylphenyl)thieno[2,3-d]pyrimidin-4-amine
• InChI: InChI=1S/C14H13N3O2S2/c1-9-7-12-13(15-8-16-14(12)20-9)17-10-3-5-11(6-4-10)21(2,18)19/h3-8H,1-2H3,(H,15,16,17)
• InChIKey: QVQHWPLHUNEREE-UHFFFAOYSA-N
• SMILES: CC1=CC2=C(N=CN=C2S1)NC3=CC=C(C=C3)S(=O)(=O)C

ARUK2001607 (Cat No.: I042358) is a potent and selective small molecule inhibitor primarily developed to target neurodegenerative disease pathways, notably in Alzheimer’s research. It acts by modulating kinase activity, influencing cellular processes related to tau phosphorylation and neuroinflammation. With high brain penetration and excellent pharmacokinetic properties, ARUK2001607 shows promise in preclinical studies for slowing disease progression. It is an important research tool for understanding the molecular mechanisms underlying cognitive decline and evaluating potential therapeutic strategies for neurodegenerative disorders.

Reference

[1]. Timothy P C Rooney, et al. The Identification of Potent, Selective, and Brain Penetrant PI5P4Kγ Inhibitors as In Vivo-Ready Tool Molecules. J Med Chem. 2022 Dec 14.
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