For research use only. Not for therapeutic Use.
ART558（Cat No.:I045272）is a potent, selective, and orally bioavailable inhibitor of ataxia telangiectasia and Rad3-related kinase (ATR), a key regulator of the DNA damage response and replication stress signaling. By blocking ATR activity, ART558 impairs cell cycle checkpoint activation and DNA repair, selectively sensitizing tumor cells—particularly those with ATM deficiency or high replication stress—to genotoxic agents. It has shown strong activity in preclinical cancer models, both as monotherapy and in combination with DNA-damaging treatments. ART558 is a valuable tool for studying ATR biology and developing targeted therapeutic strategies exploiting DNA repair vulnerabilities.
| CAS Number | 2603528-97-6 |
| Synonyms | (2S,3R)-1-[3-cyano-6-methyl-4-(trifluoromethyl)pyridin-2-yl]-3-hydroxy-N-methyl-N-(3-methylphenyl)pyrrolidine-2-carboxamide |
| Molecular Formula | C21H21F3N4O2 |
| Purity | ≥95% |
| IUPAC Name | (2S,3R)-1-[3-cyano-6-methyl-4-(trifluoromethyl)pyridin-2-yl]-3-hydroxy-N-methyl-N-(3-methylphenyl)pyrrolidine-2-carboxamide |
| InChI | InChI=1S/C21H21F3N4O2/c1-12-5-4-6-14(9-12)27(3)20(30)18-17(29)7-8-28(18)19-15(11-25)16(21(22,23)24)10-13(2)26-19/h4-6,9-10,17-18,29H,7-8H2,1-3H3/t17-,18+/m1/s1 |
| InChIKey | YHMDHAMZFMNMTF-MSOLQXFVSA-N |
| SMILES | CC1=CC(=CC=C1)N(C)C(=O)[C@@H]2[C@@H](CCN2C3=NC(=CC(=C3C#N)C(F)(F)F)C)O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
