Aromatase-IN-2

For research use only. Not for therapeutic Use.

  • CAT Number: I042477
  • CAS Number: 121768-39-6
  • Molecular Formula: C17H22N2O
  • Molecular Weight: 270.37
  • Purity: ≥95%
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Aromatase-IN-2 (Cat No.: I042477) is a synthetic small-molecule inhibitor targeting aromatase, the enzyme responsible for converting androgens into estrogens. By blocking this conversion, Aromatase-IN-2 reduces estrogen levels, making it a promising candidate for hormone-dependent cancer therapies, particularly estrogen receptor-positive (ER+) breast cancer. It is under investigation for its potency, selectivity, and pharmacokinetics in preclinical studies. Aromatase-IN-2 may also be explored for other estrogen-related conditions, offering potential benefits in managing diseases where estrogen suppression is therapeutically advantageous.


CAS Number 121768-39-6
Synonyms

N-(pyridin-4-ylmethyl)adamantane-1-carboxamide

Molecular Formula C17H22N2O
Purity ≥95%
InChI InChI=1S/C17H22N2O/c20-16(19-11-12-1-3-18-4-2-12)17-8-13-5-14(9-17)7-15(6-13)10-17/h1-4,13-15H,5-11H2,(H,19,20)
InChIKey GYWQBPYNAGLBSC-UHFFFAOYSA-N
SMILES C1C2CC3CC1CC(C2)(C3)C(=O)NCC4=CC=NC=C4
Reference

[1]. Chan FC, et al. 3- and 4-pyridylalkyl adamantanecarboxylates: inhibitors of human cytochrome P450(17 alpha) (17 alpha-hydroxylase/C17,20-lyase). Potential nonsteroidal agents for the treatment of prostatic cancer. J Med Chem. 1996 Aug 16;39(17):3319-23.
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