For research use only. Not for therapeutic Use.
ARN19874（Cat No.:I018160）is a selective small-molecule inhibitor of the sirtuin family deacetylase SIRT2, an enzyme regulating cell cycle progression, metabolism, and neurodegeneration-related pathways. By blocking SIRT2 activity, ARN19874 increases acetylation of key substrates such as α-tubulin, affecting cytoskeletal organization and cell survival. Research suggests it holds potential in studying neurodegenerative disorders like Parkinson’s and Huntington’s disease, as well as cancer biology where SIRT2 plays a role in tumor growth. ARN19874 is a valuable tool for dissecting sirtuin biology and developing targeted therapeutic strategies.
| CAS Number | 2190502-57-7 |
| Synonyms | 2,4-dioxo-N-(4-pyridin-4-ylphenyl)-1H-quinazoline-6-sulfonamide |
| Molecular Formula | C19H14N4O4S |
| Purity | ≥95% |
| IUPAC Name | 2,4-dioxo-N-(4-pyridin-4-ylphenyl)-1H-quinazoline-6-sulfonamide |
| InChI | InChI=1S/C19H14N4O4S/c24-18-16-11-15(5-6-17(16)21-19(25)22-18)28(26,27)23-14-3-1-12(2-4-14)13-7-9-20-10-8-13/h1-11,23H,(H2,21,22,24,25) |
| InChIKey | OPBGIIQHYNFABO-UHFFFAOYSA-N |
| SMILES | C1=CC(=CC=C1C2=CC=NC=C2)NS(=O)(=O)C3=CC4=C(C=C3)NC(=O)NC4=O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
