For research use only. Not for therapeutic Use.
ARN-19702（Cat No.:I045146）is a selective, reversible, and brain-penetrant inhibitor of N-acylethanolamine acid amidase (NAAA) with an IC₅₀ of ~230 nM for human NAAA. Orally bioavailable, it modulates lipid signaling pathways linked to inflammation and pain. In preclinical models, ARN-19702 provided neuroprotection in multiple sclerosis, reduced inflammatory and neuropathic pain in formalin, carrageenan, paw incision, sciatic nerve injury, and paclitaxel-induced neuropathy tests. Its dual anti-inflammatory and analgesic effects suggest therapeutic potential for pain and neuroinflammatory disorders. Currently, ARN-19702 is under preclinical investigation for central nervous system–related conditions.
| CAS Number | 1971937-18-4 |
| Synonyms | (2-ethylsulfonylphenyl)-[(2S)-4-(6-fluoro-1,3-benzothiazol-2-yl)-2-methylpiperazin-1-yl]methanone |
| Purity | ≥95% |
| IUPAC Name | (2-ethylsulfonylphenyl)-[(2S)-4-(6-fluoro-1,3-benzothiazol-2-yl)-2-methylpiperazin-1-yl]methanone |
| InChI | InChI=1S/C21H22FN3O3S2/c1-3-30(27,28)19-7-5-4-6-16(19)20(26)25-11-10-24(13-14(25)2)21-23-17-9-8-15(22)12-18(17)29-21/h4-9,12,14H,3,10-11,13H2,1-2H3/t14-/m0/s1 |
| InChIKey | UKQOLPNYRVPCBM-AWEZNQCLSA-N |
| SMILES | CCS(=O)(=O)C1=CC=CC=C1C(=O)N2CCN(C[C@@H]2C)C3=NC4=C(S3)C=C(C=C4)F |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
