For research use only. Not for therapeutic Use.
ARI-1(CAT: I040328) is a selective small-molecule inhibitor targeting receptor tyrosine kinase-like orphan receptor 1 (ROR1), a tumor-associated antigen implicated in non-small cell lung cancer (NSCLC) and resistance to EGFR tyrosine kinase inhibitors (TKIs). ARI-1 binds specifically to the extracellular Frizzled domain of ROR1, suppressing aberrant signaling and regulating the downstream PI3K/AKT/mTOR pathway in a ROR1-dependent manner. This mechanism disrupts tumor cell proliferation, migration, and survival. ARI-1 exhibits potent anti-proliferative effects in ROR1-positive NSCLC cell lines and demonstrates significant in vivo antitumor activity. It is a valuable tool for targeted cancer therapy research and resistance mechanism studies.
| Synonyms | (2R)-5,7-bis(methoxymethoxy)-2-(4-methoxyphenyl)-2,3-dihydrochromen-4-one |
| Molecular Formula | C20H22O7 |
| Purity | ≥95% |
| IUPAC Name | (2R)-5,7-bis(methoxymethoxy)-2-(4-methoxyphenyl)-2,3-dihydrochromen-4-one |
| InChI | InChI=1S/C20H22O7/c1-22-11-25-15-8-18(26-12-23-2)20-16(21)10-17(27-19(20)9-15)13-4-6-14(24-3)7-5-13/h4-9,17H,10-12H2,1-3H3/t17-/m1/s1 |
| InChIKey | PUZCVJRGJCUWMV-QGZVFWFLSA-N |
| SMILES | COCOC1=CC2=C(C(=O)CC(O2)C3=CC=C(C=C3)OC)C(=C1)OCOC |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
