Arg-Gly-Asp-Ser (CAT: I005424) is a peptide sequence derived from the extracellular matrix protein fibronectin. It is known for its ability to bind to integrin receptors, particularly integrin αvβ3, which is expressed on the surface of various cells including endothelial cells and some cancer cells. The sequence Arg-Gly-Asp (RGD) is a recognition motif for integrins and plays a crucial role in cell adhesion, migration, and signaling. By binding to integrins, Arg-Gly-Asp-Ser can modulate cell behavior, including angiogenesis (formation of new blood vessels) and tumor growth. It has been extensively studied in the development of targeted therapies for cancer and other pathological conditions where integrin signaling is involved.
Catalog Number | I005424 |
CAS Number | 91037-65-9 |
Synonyms | RGDS peptide |
Molecular Formula | C15H27N7O8 |
Purity | ≥95% |
Target | Integrin |
Solubility | DMSO: ≥ 55 mg/mL |
Storage | Desiccate at -20C |
InChIKey | NNRFRJQMBSBXGO-CIUDSAMLSA-N |
Reference | <p> |