ARB-272572

• CAT Number: I045213
• CAS Number: 2368182-63-0
• Molecular Formula: C32H36N6O4
• Molecular Weight: 568.67
• Purity: ≥95%
• Synonyms: 5-[(2-hydroxyethylamino)methyl]-N-[3-[3-[[5-[(2-hydroxyethylamino)methyl]pyridine-2-carbonyl]amino]-2-methylphenyl]-2-methylphenyl]pyridine-2-carboxamide
• InChI: InChI=1S/C32H36N6O4/c1-21-25(5-3-7-27(21)37-31(41)29-11-9-23(19-35-29)17-33-13-15-39)26-6-4-8-28(22(26)2)38-32(42)30-12-10-24(20-36-30)18-34-14-16-40/h3-12,19-20,33-34,39-40H,13-18H2,1-2H3,(H,37,41)(H,38,42)
• InChIKey: FZEPAZRIEAMJFE-UHFFFAOYSA-N
• SMILES: CC1=C(C=CC=C1NC(=O)C2=NC=C(C=C2)CNCCO)C3=C(C(=CC=C3)NC(=O)C4=NC=C(C=C4)CNCCO)C

ARB-272572（Cat No.:I045213）is a potent, selective inhibitor of mitogen-activated protein kinase kinase 5 (MAP2K5 or MEK5), a dual-specificity kinase in the MEK5–ERK5 signaling pathway that regulates cell proliferation, survival, and stress responses. By blocking MEK5 activity, ARB-272572 suppresses ERK5 phosphorylation, disrupting downstream transcriptional programs involved in cancer progression and inflammation. It is a valuable research tool for studying MEK5–ERK5 pathway biology and its role in oncogenesis, cardiovascular function, and immune regulation. ARB-272572 holds therapeutic potential for cancers and inflammatory diseases driven by aberrant MEK5–ERK5 signaling.