For research use only. Not for therapeutic Use.
APX-115（Cat No.:I018152）is a potent, orally active inhibitor of NADPH oxidase (NOX) isoforms, particularly NOX1, NOX2, and NOX4, enzymes responsible for generating reactive oxygen species (ROS). By suppressing NOX activity, APX-115 reduces oxidative stress, inflammation, and fibrosis, making it a promising candidate in research on chronic kidney disease, diabetic nephropathy, and cardiovascular disorders. Preclinical studies suggest it may protect renal and vascular function by preventing ROS-mediated tissue injury. APX-115 is a valuable tool for exploring oxidative stress–related mechanisms and therapeutic strategies in metabolic and inflammatory disease research.
| CAS Number | 1395946-75-4 |
| Synonyms | 5-phenyl-4-propyl-2-pyridin-2-yl-1H-pyrazol-3-one;hydrochloride |
| Molecular Formula | C17H18ClN3O |
| Purity | ≥95% |
| IUPAC Name | 5-phenyl-4-propyl-2-pyridin-2-yl-1H-pyrazol-3-one;hydrochloride |
| InChI | InChI=1S/C17H17N3O.ClH/c1-2-8-14-16(13-9-4-3-5-10-13)19-20(17(14)21)15-11-6-7-12-18-15;/h3-7,9-12,19H,2,8H2,1H3;1H |
| InChIKey | YEEIHSUMLNXRMI-UHFFFAOYSA-N |
| SMILES | CCCC1=C(NN(C1=O)C2=CC=CC=N2)C3=CC=CC=C3.Cl |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
