APX-115 free base (CAT: I017637), also known as Ewha-18278 free base, is a potent and orally active inhibitor of NADPH oxidase (Nox). Nox enzymes play a crucial role in the generation of reactive oxygen species (ROS) within cells. By inhibiting Nox, APX-115 free base reduces ROS production and oxidative stress. This compound has demonstrated efficacy in preclinical studies, showing its potential for various conditions associated with Nox-mediated oxidative damage, such as inflammation, cardiovascular diseases, and neurodegenerative disorders.
| Catalog Number | I017637 |
| CAS Number | 1270084-92-8 |
| Molecular Formula | C₁₇H₁₇N₃O |
| Purity | 95% |
| Reference | [1]. Kwon G, et al. A novel pan-Nox inhibitor, APX-115, protects kidney injury in streptozotocin-induced diabetic mice: possible role of peroxisomal and mitochondrial biogenesis. Oncotarget. 2017 Jun 16;8(43):74217-74232.<br>[2]. Cha JJ, et al. APX-115, a first-in-class pan-NADPH oxidase (Nox) inhibitor, protects db/db mice from renal injury. Lab Invest. 2017 Apr;97(4):419-431. |
