APX-115 free base

  • CAT Number: I017637
  • CAS Number: 1270084-92-8
  • Molecular Formula: C₁₇H₁₇N₃O
  • Molecular Weight: 279.34
  • Purity: ≥95%
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APX-115 free base (CAT: I017637), also known as Ewha-18278 free base, is a potent and orally active inhibitor of NADPH oxidase (Nox). Nox enzymes play a crucial role in the generation of reactive oxygen species (ROS) within cells. By inhibiting Nox, APX-115 free base reduces ROS production and oxidative stress. This compound has demonstrated efficacy in preclinical studies, showing its potential for various conditions associated with Nox-mediated oxidative damage, such as inflammation, cardiovascular diseases, and neurodegenerative disorders.

Catalog Number I017637
CAS Number 1270084-92-8
Molecular Formula

C₁₇H₁₇N₃O

Purity 95%
Reference

[1]. Kwon G, et al. A novel pan-Nox inhibitor, APX-115, protects kidney injury in streptozotocin-induced diabetic mice: possible role of peroxisomal and mitochondrial biogenesis. Oncotarget. 2017 Jun 16;8(43):74217-74232.<br>[2]. Cha JJ, et al. APX-115, a first-in-class pan-NADPH oxidase (Nox) inhibitor, protects db/db mice from renal injury. Lab Invest. 2017 Apr;97(4):419-431.

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