AP39

• CAT Number: I044346
• CAS Number: 1429061-80-2
• Molecular Formula: C37H38BrO2PS3
• Molecular Weight: 721.77
• Purity: ≥95%
• Synonyms: [10-oxo-10-[4-(5-sulfanylidenedithiol-3-yl)phenoxy]decyl]-triphenylphosphanium;bromide
• InChI: InChI=1S/C37H38O2PS3.BrH/c38-36(39-31-26-24-30(25-27-31)35-29-37(41)43-42-35)23-15-4-2-1-3-5-16-28-40(32-17-9-6-10-18-32,33-19-11-7-12-20-33)34-21-13-8-14-22-34;/h6-14,17-22,24-27,29H,1-5,15-16,23,28H2;1H/q+1;/p-1
• InChIKey: PUEBFERUDPTIDR-UHFFFAOYSA-M
• SMILES: C1=CC=C(C=C1)[P+](CCCCCCCCCC(=O)OC2=CC=C(C=C2)C3=CC(=S)SS3)(C4=CC=CC=C4)C5=CC=CC=C5.[Br-]

AP39（Cat No.:I044346）is a mitochondria-targeted hydrogen sulfide (H₂S) donor developed to deliver controlled amounts of H₂S directly to the mitochondria, where it exerts cytoprotective effects. It is designed with a triphenylphosphonium (TPP⁺) moiety that facilitates mitochondrial uptake. AP39 helps maintain mitochondrial function, reduce oxidative stress, and prevent apoptosis under pathological conditions such as ischemia-reperfusion injury, neurodegeneration, and inflammation. Preclinical studies have shown that AP39 enhances cell survival and bioenergetics by supporting mitochondrial respiration. Its targeted delivery makes it a promising therapeutic agent for diseases involving mitochondrial dysfunction and oxidative damage.