AP-18

• CAT Number: R016904
• CAS Number: 55224-94-7
• Molecular Formula: C11H12ClNO
• Molecular Weight: 209.67
• Purity: ≥95%
• Synonyms: (NZ)-N-[(E)-4-(4-chlorophenyl)-3-methylbut-3-en-2-ylidene]hydroxylamine
• IUPAC Name: (NE)-N-[(E)-4-(4-chlorophenyl)-3-methylbut-3-en-2-ylidene]hydroxylamine
• InChI: InChI=1S/C11H12ClNO/c1-8(9(2)13-14)7-10-3-5-11(12)6-4-10/h3-7,14H,1-2H3/b8-7+,13-9+
• InChIKey: MHTJEUOFLVQMCL-NJHPPEEMSA-N
• SMILES: C/C(=C\C1=CC=C(C=C1)Cl)/C(=N/O)/C

AP-18（Cat No.:R016904）is a selective antagonist of the TRPA1 (transient receptor potential ankyrin 1) ion channel, which plays a critical role in pain perception, inflammation, and sensory signal transduction. By blocking TRPA1 activation, AP-18 helps reduce responses to noxious stimuli such as cold, irritants, and oxidative stress. It is widely used in preclinical research to study TRPA1-mediated pathways in neuropathic pain, asthma, and inflammatory diseases. AP-18’s high specificity and potency make it a valuable pharmacological tool for validating TRPA1 as a therapeutic target in sensory and inflammatory disorders.