AOD9604

  • CAT Number: I001961
  • CAS Number: 221231-10-3
  • Molecular Formula: C78H123N23O23S2
  • Molecular Weight: 1815.1
  • Purity: 98%
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AOD9604(Cat No.:I001961)is an improved version of its predecessor AOD9401, known for its enhanced potency in stimulating lipolysis (fat burning) and exhibiting anti-adipogenic activity. Similar to human growth hormone (HGH), AOD9604 promotes the breakdown of fat through lipolysis and prevents the formation of new fat through lipogenesis. By enhancing fat metabolism and inhibiting fat storage, AOD9604 holds potential as a therapeutic agent for weight management and combating obesity-related issues.

Catalog Number I001961
CAS Number 221231-10-3
Synonyms

AOD-9604; AOD 9604; AOD9604.;L-tyrosyl-L-leucyl-L-arginyl-L-isoleucyl-L-valyl-L-glutaminyl-L-cysteinyl-L-arginyl-L-seryl-L-valyl-L-alpha-glutamyl-glycyl-L-seryl-L-cysteinyl-glycyl-L-phenylalanine (7->14)-disulfide.

Molecular Formula

C78H123N23O23S2

Purity 98
Solubility Soluble in DMSO
Storage Store at -20°C
IUPAC Name (2S)-2-[[2-[[(4R,7S,13S,16S,19S,22S,25R)-25-[[(2S)-5-amino-2-[[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]-4-methylpentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-methylpentanoyl]amino]-3-methylbutanoyl]amino]-5-oxopentanoyl]amino]-22-(3-carbamimidamidopropyl)-13-(2-carboxyethyl)-7,19-bis(hydroxymethyl)-6,9,12,15,18,21,24-heptaoxo-16-propan-2-yl-1,2-dithia-5,8,11,14,17,20,23-heptazacyclohexacosane-4-carbonyl]amino]acetyl]amino]-3-phenylpropanoic acid
InChI InChI=1S/C78H123N23O23S2/c1-9-41(8)62(101-68(115)47(18-14-28-86-78(83)84)91-69(116)50(29-38(2)3)95-63(110)45(79)30-43-19-21-44(104)22-20-43)75(122)100-61(40(6)7)74(121)94-49(23-25-56(80)105)67(114)98-55-37-126-125-36-54(65(112)88-32-57(106)89-51(76(123)12
InChIKey GVIYUKXRXPXMQM-BPXGDYAESA-N
SMILES CC[C@H](C)[C@@H](C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCCNC(=N)N)CO)C(C)C)CCC(=O)O)CO)C(=O)NCC(=O)N[C@@H](CC2=CC=CC=C2)C(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC
Reference

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1:Effect of Intra-articular Injection of AOD9604 with or without Hyaluronic Acid in Rabbit Osteoarthritis Model. Kwon DR, Park GY.Ann Clin Lab Sci. 2015 Summer;45(4):426-32. PMID: 26275694<br />
2:Detection and in vitro metabolism of AOD9604. Cox HD, Smeal SJ, Hughes CM, Cox JE, Eichner D.Drug Test Anal. 2015 Jan;7(1):31-8. doi: 10.1002/dta.1715. Epub 2014 Sep 10. PMID: 25208511<br />
3:Identification and characterization of peptide drugs in unknown pharmaceutical preparations seized by the Belgian authorities: case report on AOD9604. Vanhee C, Moens G, Deconinck E, De Beer JO.Drug Test Anal. 2014 Sep;6(9):964-8. doi: 10.1002/dta.1687. Epub 2014 Jun 26. No abstract available. PMID: 24976118<br />
4:The Effects of Human GH and Its Lipolytic Fragment (AOD9604) on Lipid Metabolism Following Chronic Treatment in Obese Mice and&beta; 3-AR Knock-Out Mice. Heffernan M, Summers RJ, Thorburn A, Ogru E, Gianello R, Jiang WJ, Ng FM.Endocrinology. 2001 Dec 1;142(12):5182-5189. doi: 10.1210/endo.142.12.8522. No abstract available. PMID: 28201187<br />
5:The effects of human GH and its lipolytic fragment (AOD9604) on lipid metabolism following chronic treatment in obese mice and beta(3)-AR knock-out mice. Heffernan M, Summers RJ, Thorburn A, Ogru E, Gianello R, Jiang WJ, Ng FM.Endocrinology. 2001 Dec;142(12):5182-9. PMID: 11713213<br />
6:Metabolic studies of a synthetic lipolytic domain (AOD9604) of human growth hormone. Ng FM, Sun J, Sharma L, Libinaka R, Jiang WJ, Gianello R.Horm Res. 2000;53(6):274-8. PMID: 11146367

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