For research use only. Not for therapeutic Use.
Antimalarial Agent 33 (CAT: I040290) is a promising antiplasmodial compound with activity against both the erythrocytic and hepatic stages of Plasmodium, including the chloroquine-resistant K1 P. falciparum strain, with an EC₅₀ of 1.1 μM. It exhibits enhanced metabolic stability in human liver microsomes (T₁/₂ = 29 minutes) and shows no significant cytotoxicity against primary hepatocytes, supporting a favorable safety profile. This compound is a valuable lead candidate for antimalarial drug development, enabling investigation of dual-stage parasite inhibition. Antimalarial Agent 33 is ideal for research in malaria pathogenesis, resistance mechanisms, and chemotherapeutic strategies.
| Synonyms | 2-(cyclobutylamino)-6-(4-methylphenyl)-3H-thieno[3,2-d]pyrimidin-4-one |
| Molecular Formula | C17H17N3OS |
| Purity | ≥95% |
| IUPAC Name | 2-(cyclobutylamino)-6-(4-methylphenyl)-3H-thieno[3,2-d]pyrimidin-4-one |
| InChI | InChI=1S/C17H17N3OS/c1-10-5-7-11(8-6-10)14-9-13-15(22-14)16(21)20-17(19-13)18-12-3-2-4-12/h5-9,12H,2-4H2,1H3,(H2,18,19,20,21) |
| InChIKey | GHKMRRXSJMTZEF-UHFFFAOYSA-N |
| SMILES | CC1=CC=C(C=C1)C2=CC3=C(S2)C(=O)NC(=N3)NC4CCC4 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
