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Anlotinib

Anlotinib

  • CAT Number: I000298
  • CAS Number: 1058156-90-3
  • Molecular Formula: C23H22FN3O3
  • Molecular Weight: 407.44
  • Purity: ≥95%
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Anlotinib (CAT: I000298) is an orally available small molecule that acts as an inhibitor of multiple receptor tyrosine kinases, including EGFR (epidermal growth factor receptor), VEGFR (vascular endothelial growth factor receptor), FGFR (fibroblast growth factor receptor), and PDGFR (platelet-derived growth factor receptor). It has shown promise as a targeted therapy for the treatment of non-small cell lung cancer (NSCLC). By inhibiting the activity of these kinases, Anlotinib can disrupt signaling pathways involved in tumor growth, angiogenesis, and metastasis. It has been investigated in clinical trials as a potential treatment option for various cancers, including NSCLC.

Catalog Number I000298
CAS Number 1058156-90-3
Molecular Formula

C23H22FN3O3

Purity 95%
Solubility DMSO: ≥ 44 mg/mL
Storage -20oC Freeze
Related CAS 1360460-82-7 (HCl salt)
InChI InChI=1S/C23H22FN3O3/c1-13-9-15-16(27-13)3-4-19(22(15)24)30-18-5-8-26-17-11-21(20(28-2)10-14(17)18)29-12-23(25)6-7-23/h3-5,8-11,27H,6-7,12,25H2,1-2H3
InChIKey KSMZEXLVHXZPEF-UHFFFAOYSA-N
SMILES CC1=CC2=C(N1)C=CC(=C2F)OC3=C4C=C(C(=CC4=NC=C3)OCC5(CC5)N)OC
Reference

<p>
[1]. PCT Int. Appl. (2015), WO 2015185012 A1 20151210. <br />
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