Anisomycin

• CAT Number: I002743
• CAS Number: 22862-76-6
• Molecular Formula: C₁₄H₁₉NO₄
• Molecular Weight: 265.3
• Purity: ≥95%
• Target: JNK
• Solubility: 10 mM in DMSO
• Storage: Desiccate at +4°C
• InChI: InChI=1S/C14H19NO4/c1-9(16)19-14-12(15-8-13(14)17)7-10-3-5-11(18-2)6-4-10/h3-6,12-15,17H,7-8H2,1-2H3/t12-,13+,14+/m1/s1
• InChIKey: YKJYKKNCCRKFSL-RDBSUJKOSA-N
• SMILES: CC(=O)OC1C(CNC1CC2=CC=C(C=C2)OC)O

Anisomycin(CAT: I002743) is a naturally occurring antibiotic and protein synthesis inhibitor. It is derived from the bacterium Streptomyces griseous. Anisomycin inhibits protein synthesis by blocking the translocation step during translation, thereby preventing the formation of new proteins. It has been widely used as a research tool in various biological studies, including the study of cellular signaling pathways, gene expression, and apoptosis. Anisomycin has also demonstrated anti-cancer properties and has been investigated for its potential therapeutic applications in cancer treatment.

Reference

1: GONZALEZ CONSTANDSE R. [Anisomycin in intestinal amebiasis; study of 30
clinical cases]. Prensa Med Mex. 1956 Sep-Dec;21(7-10):114-5. Spanish. PubMed
PMID: 13408199.

2: GARDOCKI JF, TIMMENS EK, WILSON LB, SODERGREN JO, HETTINGER BR, P/’AN SY. Acute
and chronic toxicity of anisomycin in experimental animals. Antibiot Chemother
(Northfield). 1955 Sep;5(9):490-5. PubMed PMID: 24543705.

3: LYNCH JE, HOLLEY EC, SALMIRS AM. Effect of anisomycin on the growth of
Trichomonas vaginalis. Antibiot Chemother (Northfield). 1955 May;5(5):300-4.
English, German. PubMed PMID: 24543480.

4: LYNCH JE, ENGLISH AR, MORRISON J, MAVEN I. Protective action of anisomycin in
mice infected with Trichomonas foetus. Antibiot Chemother (Northfield). 1954
Aug;4(8):899-904. PubMed PMID: 24543217.

5: LYNCH JE, ENGLISH AR, BAUCK H, DELIGIANIS H. Studies on the in vitro activity
of anisomycin. Antibiot Chemother (Northfield). 1954 Aug;4(8):844-8. PubMed PMID:
24543208.